The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, who smoke, or who drink large amounts of alcohol while taking ibuprofen. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. If you will be undergoing a coronary artery bypass graft (CABG a type of heart surgery), you should not take ibuprofen right before or right after the surgery. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke if you smoke and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Do not take an NSAID such as ibuprofen if you have recently had a heart attack, unless directed to do so by your doctor. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. These events may happen without warning and may cause death. What is coronary artery disease? A Mayo Clinic cardiologist explains.People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications.
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